• br AUTHOR CONTRIBUTIONS br JL PJM and

  2022-05-13

  

  AUTHOR CONTRIBUTIONS JL, PJM and LZP conceived and designed the study. JL, PJM, RY and JEV performed experiments. JL analyzed and interpreted the experi-mental data. MM, JMS and THV scored the TMAs. RY and EXC per-formed the HPLC-MS/MS analysis. YW provided the PDX model. DTSW, RJH and NEF prov

• br Particle morphology br The morphology of three selected

  2022-05-10

  

  3.2. Particle morphology The morphology of three-selected α-mangostin loaded FNPs are il-lustrated in Fig. 1, TEM micrographs. Generally, all formulas showed a monodispersed pattern with 300-nm spherical particles, in agreement with the DLS method. The α-mangostin-EDClow-FNP demonstrated a roug

• br Results br Internal interaction between AKT and HK br

  2022-05-10

  

  3. Results 3.1. Internal interaction between AKT2 and HK2 The overexpression and/or constitutive activation of AKT2 has been well documented in the involvement of multiple cancers, including colon cancer [19]. In addition, in some studies, HK2 has been im-plicated as a potential downstream m

• br Chemotherapy br Concurrent chemoradiotherapy CCTRT was delivered in a

  2022-05-09

  

  2.4. Chemotherapy Concurrent chemoradiotherapy (CCTRT) was delivered in a total of 109 patients; the most common regimen was weekly cisplatin at 40 mg/m2 for 5 cycles. Adjuvant CT, generally 4 to 6 cycles of carboplatin and paclitaxel, was delivered after RT in 108 patients. Absolute neutro-phi

• br Tumor cell metastasis requires

  2022-05-09

  

  Tumor cell metastasis requires a coordinated sequence of multiple events, including tumor-host interactions and prometastatic molecular regulators. Many activated transcriptional factors can modulate the expression of posttranscriptional regulators in tumor DTT to regulate tumor metastasis. For e

• br Western blot was performed as previously described

  2022-05-09

  

  Western blot was performed as previously described [19]. Briefly, cell cultures were washed with PBS, scraped in RIPA buffer and cen-trifuged at 5000g for 10 min. Total protein lysis (40 µg) was separated on SDS-PAGE, electro-transferred to polyvinylidene fluoride mem-branes and then incubated with

• Oxaliplatin Consumers e misunderstandings about BC risk management br Consumers

  2022-05-09

  

  3.3. Consumers e misunderstandings about BC risk management Consumers were all aware of BreastScreen (the Australian population screening program), and those aged over 50 years had all attended BreastScreen at least once. Yet we identified mis-understandings related to breast self-examination, li

• br A Schaudinn et al br dominant

  2022-05-07

  

  A. Schaudinn, et al. dominant sequences for TZ (T2w) and PZ (DWI) [4]. DCE was analyzed for PZ lesions in case of a DWI score of 3. Lesions were assigned to a single zone only if the respective cancer volume (3D) exceeded 70%. 2.5. Radiologic-pathologic correlation Section slides were dig

• br Results br Patient characteristics br Patients were included in

  2022-05-06

  

  3. Results 3.1. Patient characteristics Patients were included in the present study when confirmed ALK positive by at least one method. Totally, 55 ALK-positive patients with a median age of 54 years (range, 27–73 years) were evaluated. The clinicopathologic profiles of the patients were dis

• br MRI br MRI produces detailed pictures

  2022-05-06

  

  MRI MRI produces detailed pictures of a patient’s breast. It can detect high-grade ductal carcinoma in situ. A retrospective study discov-ered that an MRI test had higher cancer detection rates than a mammogram test with a sensitivity result of 92.3% versus 30.8%, but it had a lower specificity

• br electronically excited atoms reactive species etc Reactive species

  2022-05-04

  

  electronically excited atoms, reactive species, etc [20–23]. Reactive species are known to promote cell proliferation as well as cell death [24–26]. Additionally, extreme amounts of reactive species may lead to the damage of DNA, proteins, lipids, senescence and induce apoptosis [7,24]. Many publi

• br Materials and methods br Materials cell

  2022-05-04

  

  2. Materials and methods 2.1. Materials, cell culture and animals Soy Lecithin (S100) was purchased from Advanced Viecle Technology L.T.D. Co. (Shanghai, China). Scrambled siRNA (siN.C.) and siHSP70 (sense strand: 5′- CUUGUGCUCAAACUCGUCCdTdT-3′, anti-sense strand: 3′- GAACACGAGUUUGAGCAGGdTdT

• br Quality control of intrinsically radiolabeled AuNP RGD

  2022-04-29

  

  2.7. Quality control of intrinsically radiolabeled 198AuNP-RGD The radionuclidic purity of 198AuNP-RGD was analyzed by high res-olution γ-ray spectrometry using HPGe detector coupled with multi-channel analyzer (Canberra, Eurisys, France), as per the standard procedure [14]. The radiochemical p

• br Functional outcomes of facial weakness

  2022-04-29

  

  Functional outcomes of facial weakness Next, the functional outcomes of facial APTSTAT3-9R were assessed according to treatment modality. Post-treatment facial function was evaluated at 6–12 months after completing treatment (Supplementary Fig. S2). Facial function in nerve-resected patients w

• br Li H Zhu XR Zhang X Reducing dose uncertainty

  2022-04-29

  

  [15] Li H, Zhu XR, Zhang X. Reducing dose uncertainty for spot-scanning Pifithrin-α beam therapy of moving tumors by optimizing the spot delivery sequence. Int J Radiat Oncol Biol Phys 2015;93:547–56. [16] Stata. Release 15 ed. College Station, TX: StataCorp LP; 2017. p. Statistical Software.

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